At the forefront of lung 癌症 treatment
首页 / 澳门第一赌城在线娱乐的治疗领域 / 肿瘤学 /肺癌
肺癌是全球癌症死亡的主要原因，约占全球癌症死亡人数的2%.2 million patients diagnosed and 1.8 million deaths each year.1 肺癌的两种主要类型是非小细胞肺癌(NSCLC)。, which represents 80-85% of patients, and small cell lung 癌症 (SCLC), the more aggressive and fast-growing 癌症 type, representing about 15% of patients.2-3
澳门第一赌城在线娱乐越早发现和治疗肺癌，澳门第一赌城在线娱乐就越接近治愈.4-5 Unfortunately, early diagnosis is not always a reality.6
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在很多情况下, 肺癌在进入晚期或经过初步治疗后复发时才会被发现.6 对于这些复发的患者，预后尤其差.4-5 To meaningfully improve outcomes, 澳门第一赌城在线娱乐正在优先考虑肺癌研究，以增加早期筛查和诊断，并解决在疾病连续体的每个阶段对治疗的重大未满足需求.
澳门第一赌城在线娱乐的方法
澳门第一赌城在线娱乐已批准和潜在的后期开发新药组合涵盖不同的组织, several stages of disease, lines of therapy and modes of action.7 澳门第一赌城在线娱乐的方法 is driven by precision medicine, 使用突破性的科学来加深澳门第一赌城在线娱乐对肺癌的了解，并提供与患者相匹配的药物，使他们能够最大限度地从中受益. 这包括以不同的方式思考肺癌的潜在生物学, 从早期阶段——澳门第一赌城在线娱乐的目标是帮助患者活得更长、没有癌症——到晚期阶段, where we look to meaningfully extend survival.
Our scientific platforms
Tumour drivers and resistance (TDR)
澳门第一赌城在线娱乐正在定义新的生物标志物和治疗靶点，以改变肺癌的诊断和治疗方式. 澳门第一赌城在线娱乐的研究使澳门第一赌城在线娱乐能够解决表皮生长因子受体(EGFR)突变患者的未满足需求. We are also investigating resistance mechanisms and emerging biomarkers, such as alterations in the MET gene, 为了帮助回答那些尽管接受了今天的标准治疗，但癌症仍在恶化的患者接下来会发生什么.
Antibody drug conjugates (ADCs)
澳门第一赌城在线娱乐正在研究抗体药物偶联物(adc)，以靶向可操作的生物标志物，如人表皮生长因子2 (HER2)。. 不像传统的化疗会损害健康细胞, adc可以将抗癌药物直接输送到癌细胞中，以减少对健康细胞造成的损害. 目前, 肿瘤表达HER2且治疗后进展的患者选择有限, as there are no available HER2 directed medicines approved in NSCLC.
Immuno-oncology (IO)
免疫疗法旨在针对癌症利用的免疫检查点，以避免或抑制免疫系统识别和摧毁癌细胞的能力. Across our clinical trials, 澳门第一赌城在线娱乐正在测试IO作为单一疗法(单独)以及与化疗联合使用, 小分子, 抗体药物偶联物和其他免疫疗法跨越多种肿瘤类型, stages of disease and lines of treatment.
Advancing treatments through innovative trial design
虽然许多新的治疗方法都集中在推进对转移性患者的护理与高度未满足的医疗需求, we prioritised pushing treatment into earlier lung 癌症 settings. To really cure 癌症, 澳门第一赌城在线娱乐需要尽早治疗，以最大限度地提高长期疾病缓解和治愈的可能性.6 In pursuit of this goal, 澳门第一赌城在线娱乐已经启动了十多个II期和III期临床试验，评估澳门第一赌城在线娱乐的免疫肿瘤学和基因靶向治疗在疾病早期阶段的效果.7 In the Immuno-肿瘤学 space alone, 澳门第一赌城在线娱乐现在在整个行业中以最大比例的早期疾病III期试验处于领先地位, with many ongoing across the NSCLC and SCLC settings.7
Downloadable infographics
Changing the pace of progress in lung 癌症 survival
As a founding member of the Lung Ambition Alliance, 组织的伙伴关系，推动有意义的改善肺癌患者, 澳门第一赌城在线娱乐有一个雄心勃勃的目标，即消除肺癌这一致死原因. 为了实现这一目标，联盟主张在三个关键领域改进方法-
1. Increasing screening rates and diagnostic testing.
2. Accelerating the delivery of innovative medicine.
3. Improving quality of care.
Recent and ongoing initiatives include policy reports, 就像 Lung Cancer 筛选: The Cost of Inaction which outlines the opportunity presented by lung 癌症 screening to reduce costs while saving lives; strategic global, regional and local collaborations, 就像 爱的人 using artificial intelligence to improve early lung 癌症 diagnoses; the ILC2 补助计划 which funds non-profit initiatives with transformative potential for patient care; and efforts to study oncology endpoints to accelerate drug approvals in earlier settings of lung 癌症.8
Other key disease areas
加入澳门第一赌城在线娱乐
We are driven by our passion, our people and a culture of innovation. 澳门第一赌城在线娱乐重视勇气, 好奇心, collaboration and passion for learning, 澳门第一赌城在线娱乐鼓励颠覆性思维，在这种思维中，失败是一个学习的机会——可以自由地承担风险，而不必担心失败.
澳门第一赌城在线娱乐的人民
“我热衷于开发药物，以改善癌症患者的治疗效果，并培养团队成员的技能和经验。” Susan Galbraith, Executive Vice-President, 肿瘤学 R&D
参考文献
- World Health Organization. Globocan 2020 Fact Sheet. Available at: http://gco.研究.fr/today/data/factsheets/populations/900-world-fact-sheets.pdf. Accessed September 2021.
- American Cancer Society. What is Lung Cancer? Available at: http://www.癌症.org/癌症/lung-癌症/about/what-is.html. Accessed September 2021.
- National Cancer Institute. NCI Dictionary - Small Cell Lung Cancer. Available at: http://www.癌症.gov/publications/dictionaries/癌症-terms/def/small-cell-lung-癌症. Accessed September 2021.
- ASCO. Lung Cancer - Small Cell. Available at: http://www.癌症.net/癌症-types/33776/view-all. Accessed September 2021.
- ASCO. Lung Cancer - Non-Small Cell. Available at: http://www.癌症.net/癌症-types/lung-癌症/view-all. Accessed September 2021.
- LUNGevity Foundation. 筛选 & 早期检测. Available at: http://lungevity.org/for-patients-caregivers/lung-癌症-101/screening-early-detection. Accessed September 2021.
- 澳门在线赌城娱乐. Clinical trials appendix. H1 2021 results update. Available at: http://www.AstraZeneca PLC.com/content/dam/az/PDF/2021/h1-2021/H1_2021_results_clinical_trials_appendix.pdf. Accessed September 2021.
- Lung Ambition Alliance. Available at: http://www.lungambitionalliance.com. Accessed September 2021.