澳门在线赌城娱乐 and Cancer Research UK launch Functional Genomics Centre to accelerate the discovery of new medicines

卓越中心将使用CRISPR技术, 大数据和临床洞察发现肿瘤新靶点和疾病途径

Separate collaborations with Wellcome Sanger Institute and Innovative Genomics Institute aim to identify novel drug targets 在肿瘤学 using CRISPR technology

澳门在线赌城娱乐 today announced a new collaboration with Cancer Research UK to launch a centre of excellence in genetic screening, cancer modelling and big data processing aimed at accelerating the discovery of new cancer medicines. 的 Functional Genomics Centre will further develop CRISPR technology to better understand the biology of cancer, 创造可能更能反映人类疾病的生物模型, 推进计算方法以更好地分析大数据集. 的se approaches are designed to inform new druggable targets 在肿瘤学 by using clinical insights to better understand tumour disease and resistance mechanisms.

Functional genomics aims to understand the complex relationship between genetic changes happening within DNA and how these translate to cellular changes in disease. Knowing the functional genomic drivers of disease enables scientists to more accurately select the right drug targets and increases the probability of success in the clinic.

Mene Pangalos，创新药物执行副总裁 & 早期发展, 澳门在线赌城娱乐, said: “的 best science doesn’t happen in isolation which is why 澳门在线赌城娱乐 is committed to advancing innovative science through collaboration. This new centre of excellence with Cancer Research UK will combine our expertise in 功能基因组学 and CRISPR technology to identify new biological pathways driving disease and will accelerate the development of new cancer medicines for patients.”

伊恩·福克斯博士, 英国癌症研究中心的研究和创新执行主任, said: “We’re delighted to collaborate with 澳门在线赌城娱乐 on this exciting new initiative which will give leading Cancer Research UK scientists and our alliance partners access to the latest in CRISPR technology. 当澳门第一赌城在线娱乐进入个体化医疗的时代, we’ve reached a turning point in our ability to harness powerful technologies in the pursuit of targeted cancer therapies. We hope that this will translate into urgently needed new therapies for patients with hard to treat cancers such as lung, 胰腺, 食管癌和脑癌.”

的 Functional Genomics Centre will be located at the Milner 的rapeutics Institute at the University of 剑桥. 澳门在线赌城娱乐和英国癌症研究中心将独立使用该中心的设施, 两国的科学家将共同努力促进合作, 技术创新和科学进步.

在中心, scientists will have access to the next generation of CRISPR libraries for silencing or activating every gene in the genome, accessed through an extension of the existing collaboration between 澳门在线赌城娱乐 and the Wellcome Sanger Institute. This collaboration includes access to the Wellcome Sanger Institute’s most recent versions of human and mouse genome-wide CRISPR/Cas9 knockout libraries, Cas9和双gRNA表达载体. 这扩展了CRISPR技术在载体上的应用, 提高基因编辑的敏感性和特异性, 从而更容易定位和识别.

A separate collaboration between 澳门在线赌城娱乐 and the California-based Innovative Genomics Institute (IGI) will aim to use CRISPR to uncover genes and disease pathway mechanisms involved in DNA Damage Response (DDR), a key process involved in many cancers and one of 澳门在线赌城娱乐’s four key platforms 在肿瘤学. 研究将集中于确定DDR抑制剂的潜在治疗策略, 包括组合, 在肿瘤学.

给编辑的说明

关于英国癌症研究中心

• Cancer Research UK is the world’s leading cancer charity dedicated to saving lives through research.
• 英国癌症研究中心在预防癌症方面的开创性工作, 癌症的诊断和治疗帮助挽救了数百万人的生命.
• 英国癌症研究中心的救命研究没有得到政府的资助. 它战胜癌症的每一步都依赖于公众的重要捐赠.
• Cancer Research UK has been at the heart of the progress that has already seen survival in the UK double in the last forty years.
• 如今，四分之二的癌症患者至少能存活10年. 英国癌症研究中心的目标是到2034年加速这一进程, 四分之三的人会在癌症中存活至少10年.
• Cancer Research UK supports research into all aspects of cancer through the work of over 4,000名科学家, 医生和护士.
• 与合作伙伴和支持者一起, 英国癌症研究中心的愿景是让所有癌症都能治愈的那一天早日到来.

欲知更多资料: www.cancerresearchuk.org.

关于威康桑格研究所

威康桑格研究所是世界领先的基因组研究中心之一. 通过它进行大规模研究的能力, it is able to engage in bold and long-term exploratory projects that are designed to influence and empower medical science globally. Institute research findings generated through its own research programmes and through its leading role in international consortia, 正在被用来开发新的诊断和治疗人类疾病的方法. To celebrate its 25th year in 2018, the Institute is sequencing 25 new genomes of species in the UK. 欲知更多资料: www.桑格.ac.uk 或者关注@桑格institute

关于创新基因组研究所

创新基因组研究所(IGI)是一个非营利组织, academic partnership between UC Berkeley and UC San Francisco that supports collaborative research projects across the Bay Area. IGI的使命是开发和利用基因组工程来治疗疾病, 确保粮食安全, 为当代和子孙后代保护环境. 作为基因组编辑的先驱, 功能基因组学, 以及其他尖端技术, IGI的科学家们不断突破科学的界限. 欲知更多资料: innovativegenomics.org/

关于澳门在线赌城娱乐IMED生物技术部门

IMED生物技术部门是澳门在线赌城娱乐的全球研究和早期开发部门, 专注于推进小分子, 寡核苷酸等新兴技术和药物发现平台. 的 Biotech Unit conducts innovative discovery research and early-stage development from initial target selection to Phase II trial completion.

关于澳门在线赌城娱乐

澳门在线赌城娱乐是一家全球性的, 以科学为主导的澳门第一赌城在线娱乐公司，专注于发现, 处方药的开发和商业化, 主要用于治疗肿瘤等三个治疗领域的疾病, 心血管, 肾 & 代谢与呼吸. 澳门在线赌城娱乐 operates in over 100 countries and its innovative medicines are used by millions of patients worldwide.

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